Fc Receptor (FcR)
Fc Receptor
Fc Receptors (FcR) are a class of cell surface receptors that can recognize and bind to the Fc region of immunoglobulins, playing an important role in processes such as the immune response and immune regulation. According to the types of immunoglobulins they recognize, FcR can be classified into FcγR, FcεR, FcαR, etc. According to their functional characteristics, they can be divided into activating FcR and inhibitory FcR. FcR mediate the phagocytosis of immune cells, prompting phagocytes to eliminate antigenic foreign substances such as pathogens. FcR also participate in ADCC, which activates NK cells and other cells to kill target cells, affecting the immune response. In addition, FcR can clear immune complexes and prevent them from depositing in tissues and triggering inflammation. Abnormal functions or dysregulated expressions of FcR can lead to autoimmune diseases and allergic diseases. In tumors, FcR are involved in both the immune escape of tumor cells and can serve as targets for immunotherapy[1][2].
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Fc Receptor (FcR) Related Products (70)
Related Products (70)
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Rabbit IgG Fc fragment
0 ImagesCat. No.: HY-NP0198A
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BTK-IN-49
0 ImagesCat. No.: HY-182943BTK-IN-49 is a selective, orally active and brain-penetrant BTK inhibitor with an IC50 of 0.14 nM. BTK-IN-49 binds to BTK and blocks B-cell receptor and Fcγ receptor signaling. BTK-IN-49 inhibits the proliferation of CNS-compartmentalized B-cells and FcγR-induced microglial proliferation in a BTK-dependent manner. BTK-IN-49 can be used for the study of multiple sclerosis.
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hIgG-hFc receptor-IN-1
0 ImagesCat. No.: HY-145775CAS No.: 1425051-22-4hIgG–hFc receptor-IN-1 (comp 66) is a human immunoglobulin G–human neonatal Fc receptor (hIgG–hFcRn) protein-protein interaction inhibitor, with an IC50 of 2 μM .
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BTL-MK
0 ImagesCat. No.: HY-158316CAS No.: 2758569-43-4BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC50 of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumin, low endotoxin (HY-W250978A)-induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability.
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Anti-Human/Monkey CD16a Antibody (3G8)
0 ImagesCat. No.: HY-P991998Anti-Human/Monkey CD16a Antibody (3G8) is a monoclonal antibody targeting CD16a. Anti-Human/Monkey CD16a Antibody (3G8) blocks FcγRIII/CD16a, upregulates the metabolic activity of CD16+ cells, downregulates CD87, a poor prognostic marker, and inhibits the engraftment and growth of leukemia cells in acute myeloid leukemia, and rapidly increases platelet counts in immune thrombocytopenia. Anti-Human/Monkey CD16a Antibody (3G8) is applicable to research related to tumor immunology.
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Mouse IgG Fab fragment
0 ImagesCat. No.: HY-NP0196E
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Anti-CD16a Antibody (3G8)
0 ImagesCat. No.: HY-P991997Anti-CD16a Antibody (3G8) is a pan-CD16-specific antibody. Anti-CD16a Antibody (3G8) binds to an epitope overlapping with CD16a’s Fc binding site, inhibiting CD16a-IgG Fc region interactions.Anti-CD16a Antibody (3G8) recognizes CD16a, CD16b, and CD16b-NA1 and NA2 allelotypes expressed by neutrophils.
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Goat IgG Fc fragment
0 ImagesCat. No.: HY-NP0197A
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Phlorofucofuroeckol A
0 ImagesCat. No.: HY-N11725CAS No.: 128129-56-6Phlorofucofuroeckol A is a FcεRI inhibitor with low cytotoxicity toward basophilic leukemia cells. Phlorofucofuroeckol A suppresses binding activity between IgE and FcεRI receptor. Phlorofucofuroeckol A inhibits histamine release from basophilic leukemia cells stimulated by IgE/anti-IgE or calcium ionophore A23187 (HY-N6687). Phlorofucofuroeckol A inhibits β-hexosaminidase release from basophilic leukemia cells stimulated by IgE/DNP-BSA. Phlorofucofuroeckol A can be used for the research of allergy disease.
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Tricetinidin chloride
0 ImagesCat. No.: HY-N17651CAS No.: 65618-21-5Tricetinidin chloride is an antioxidant. Tricetinidin chloride protects rat renal cells against oxidative stress and DNA damage by reducing ROS production, increasing GSH levels, restoring mitochondrial membrane potential, and upregulating HO-1 expression. Tricetinidin chloride also inhibits the expression of IgE receptors on human mast cells. Tricetinidin chloride can be used in the research of inflammatory and allergic diseases.
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SYN1436
0 ImagesSYN1436 is a selective human neonatal Fc receptor (hFcRn) antagonist with an IC50 of 2.4 nM. SYN1436 binds to hFcRn and inhibits hFcRn-hIgG interaction. SYN1436 can be used for the research of autoimmune diseases.
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hIgG-hFc receptor-IN-2
0 ImagesCat. No.: HY-187393CAS No.: 1425051-06-4hIgG-hFc receptor-IN-2 is a hFcRn inhibitor with an IC50 of 6 μM for human hFcRn. hIgG-hFc receptor-IN-2 blocks the protein-protein interaction between human IgG and the soluble extracellular domain of hFcRn. hIgG-hFc receptor-IN-2 serves as a tool for studying FcRn biology and a starting point for developing orally available small molecule hFcRn inhibitors. hIgG-hFc receptor-IN-2 can be used for the research of autoimmune disease.
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hIgG-hFc receptor-IN-3
0 ImagesCat. No.: HY-187394CAS No.: 1425050-80-1hIgG-hFc receptor-IN-3 is a protein-protein interaction inhibitor of human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn). Identified via virtual ligand screening and optimized through structure-activity relationship studies, hIgG-hFc receptor-IN-3 competitively inhibits the binding of IgG to FcRn, thereby accelerating the clearance of endogenous IgG. hIgG-hFc receptor-IN-3 can be used for the research of autoimmune diseases.
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Goat IgG Fab fragment
0 ImagesCat. No.: HY-NP0197B
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SIWA318H
0 ImagesCat. No.: HY-P992465SIWA318H is an adbanvced glycation end product (AGE) specific antibody. SIWA318H selectively binds to advanced glycation end product biomarkers, human FcγRIIIa, and pancreatic cancer cells, and cancer-associated fibroblasts. SIWA318H suppresses tumor growth in mouse PSN1 xenografts. SIWA318H can be used for the research of pancreatic cancer.
